| Date | Home | Away | Result |
|---|---|---|---|
| 23/02/21 19:00 | Middlesbrough FC | Bristol City | 1-3 |
| 23/02/21 19:00 | Birmingham City | Norwich City | 1-3 |
| 23/02/21 19:00 | Derby County | Huddersfield Town | 2-0 |
| 23/02/21 19:45 | Wycombe Wanderers | Reading FC | 1-0 |
| 23/02/21 19:45 | Luton Town | Millwall FC | 1-1 |
| 23/02/21 19:45 | Rotherham United | Nottingham Forest | 0-1 |
| 24/02/21 19:00 | Barnsley FC | Stoke City | 2-0 |
| 24/02/21 19:00 | Swansea City | Coventry City | 1-0 |
| 24/02/21 19:00 | Brentford FC | Sheffield Wednesday | 3-0 |
| 24/02/21 19:45 | Preston North End | Queens Park Rangers | 0-0 |
| 24/02/21 19:45 | AFC Bournemouth | Cardiff City | 1-2 |
| 24/02/21 19:45 | Blackburn Rovers | Watford FC | 2-3 |