| Date | Home | Away | Result |
|---|---|---|---|
| 19/02/21 19:45 | Watford FC | Derby County | 2-1 |
| 20/02/21 12:30 | Coventry City | Brentford FC | 2-0 |
| 20/02/21 15:00 | Sheffield Wednesday | Birmingham City | 0-1 |
| 20/02/21 15:00 | Queens Park Rangers | AFC Bournemouth | 2-1 |
| 20/02/21 15:00 | Stoke City | Luton Town | 3-0 |
| 20/02/21 15:00 | Nottingham Forest | Blackburn Rovers | 1-0 |
| 20/02/21 15:00 | Reading FC | Middlesbrough FC | 0-2 |
| 20/02/21 15:00 | Bristol City | Barnsley FC | 0-1 |
| 20/02/21 15:00 | Cardiff City | Preston North End | 4-0 |
| 20/02/21 15:00 | Huddersfield Town | Swansea City | 4-1 |
| 20/02/21 15:00 | Norwich City | Rotherham United | 1-0 |
| 20/02/21 15:00 | Millwall FC | Wycombe Wanderers | 0-0 |