| Date | Home | Away | Result |
|---|---|---|---|
| 16/02/21 19:00 | Stoke City | Sheffield Wednesday | 1-0 |
| 16/02/21 19:00 | Preston North End | Watford FC | 0-1 |
| 16/02/21 19:45 | Middlesbrough FC | Huddersfield Town | 2-1 |
| 16/02/21 19:45 | Bristol City | Reading FC | 0-2 |
| 16/02/21 19:45 | Wycombe Wanderers | Derby County | 1-2 |
| 16/02/21 20:15 | Luton Town | Cardiff City | 0-2 |
| 17/02/21 19:00 | Coventry City | Norwich City | 0-2 |
| 17/02/21 19:00 | Millwall FC | Birmingham City | 2-0 |
| 17/02/21 19:00 | Swansea City | Nottingham Forest | 1-0 |
| 17/02/21 19:00 | Queens Park Rangers | Brentford FC | 2-1 |
| 17/02/21 19:45 | Barnsley FC | Blackburn Rovers | 2-1 |
| 17/02/21 20:15 | AFC Bournemouth | Rotherham United | 1-0 |