| Date | Home | Away | Result |
|---|---|---|---|
| 26/12/20 15:00 | Queens Park Rangers | Swansea City | 0-2 |
| 26/12/20 15:00 | Reading FC | Luton Town | 2-1 |
| 26/12/20 15:00 | Bristol City | Wycombe Wanderers | 2-1 |
| 26/12/20 15:00 | Blackburn Rovers | Sheffield Wednesday | 1-1 |
| 26/12/20 15:00 | Barnsley FC | Huddersfield Town | 2-1 |
| 26/12/20 15:00 | Coventry City | Stoke City | 0-0 |
| 26/12/20 15:00 | Derby County | Preston North End | 0-1 |
| 26/12/20 15:00 | Cardiff City | Brentford FC | 2-3 |
| 26/12/20 15:00 | Nottingham Forest | Birmingham City | 0-0 |
| 26/12/20 19:45 | Watford FC | Norwich City | 1-0 |
| 12/01/21 19:45 | AFC Bournemouth | Millwall FC | 1-1 |
| 27/01/21 19:00 | Middlesbrough FC | Rotherham United | 0-3 |