| Date | Home | Away | Result |
|---|---|---|---|
| 18/12/20 20:00 | Preston North End | Bristol City | 1-0 |
| 19/12/20 12:30 | Norwich City | Cardiff City | 2-0 |
| 19/12/20 15:00 | Huddersfield Town | Watford FC | 2-0 |
| 19/12/20 15:00 | Swansea City | Barnsley FC | 2-0 |
| 19/12/20 15:00 | Sheffield Wednesday | Coventry City | 1-0 |
| 19/12/20 15:00 | Wycombe Wanderers | Queens Park Rangers | 1-1 |
| 19/12/20 15:00 | Luton Town | AFC Bournemouth | 0-0 |
| 19/12/20 15:00 | Brentford FC | Reading FC | 3-1 |
| 19/12/20 15:00 | Birmingham City | Middlesbrough FC | 1-4 |
| 19/12/20 15:00 | Stoke City | Blackburn Rovers | 1-0 |
| 19/12/20 15:00 | Millwall FC | Nottingham Forest | 1-1 |
| 03/02/21 19:00 | Rotherham United | Derby County | 3-0 |