| Date | Home | Away | Result |
|---|---|---|---|
| 18/09/18 19:45 | Derby County | Blackburn Rovers | 0-0 |
| 18/09/18 19:45 | Aston Villa | Rotherham United | 2-0 |
| 18/09/18 19:45 | Ipswich Town | Brentford FC | 1-1 |
| 18/09/18 19:45 | Wigan Athletic | Hull City A.F.C. | 2-1 |
| 18/09/18 19:45 | Leeds United | Preston North End | 3-0 |
| 18/09/18 20:00 | Stoke City | Swansea City | 1-0 |
| 18/09/18 20:00 | West Bromwich Albion | Bristol City | 4-2 |
| 19/09/18 19:45 | Middlesbrough FC | Bolton Wanderers | 2-0 |
| 19/09/18 19:45 | Sheffield United | Birmingham City | 0-0 |
| 19/09/18 19:45 | Nottingham Forest | Sheffield Wednesday | 2-1 |
| 19/09/18 19:45 | Queens Park Rangers | Millwall FC | 2-0 |
| 19/09/18 20:00 | Reading FC | Norwich City | 1-2 |