| Date | Home | Away | Result |
|---|---|---|---|
| 21/10/17 15:00 | Aston Villa | Fulham FC | 2-1 |
| 21/10/17 15:00 | Wolverhampton Wanderers | Preston North End | 3-2 |
| 21/10/17 15:00 | Middlesbrough FC | Cardiff City | 0-1 |
| 21/10/17 15:00 | Bristol City | Leeds United | 0-3 |
| 21/10/17 15:00 | Barnsley FC | Hull City A.F.C. | 0-1 |
| 21/10/17 15:00 | Sheffield United | Reading FC | 2-1 |
| 21/10/17 15:00 | Nottingham Forest | Burton Albion | 2-0 |
| 21/10/17 15:00 | Derby County | Sheffield Wednesday | 2-0 |
| 21/10/17 15:00 | Bolton Wanderers | Queens Park Rangers | 1-1 |
| 21/10/17 15:00 | Brentford FC | AFC Sunderland | 3-3 |
| 21/10/17 17:30 | Millwall FC | Birmingham City | 2-0 |
| 22/10/17 12:00 | Ipswich Town | Norwich City | 0-1 |