Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/08/21 19:45 | 17/08/21 19:45 | Barnsley FC | Luton Town | 0-1 | 4 - 5 - 8 |
| 17/08/21 19:45 | 17/08/21 19:45 | FC Blackpool | Coventry City | 0-1 | 6 - 5 - 5 |
| 17/08/21 19:45 | 17/08/21 19:45 | Huddersfield Town | Preston North End | 1-0 | 4 - 6 - 5 |
| 17/08/21 19:45 | 17/08/21 19:45 | Millwall FC | Fulham FC | 1-2 | 9 - 10 - 3 |
| 17/08/21 19:45 | 17/08/21 19:45 | Peterborough United | Cardiff City | 2-2 | 7 - 7 - 4 |
| 17/08/21 19:45 | 17/08/21 19:45 | Swansea City | Stoke City | 1-3 | 4 - 6 - 6 |
| 17/08/21 20:00 | 17/08/21 20:00 | Reading FC | Bristol City | 2-3 | 4 - 8 - 8 |
| 18/08/21 19:45 | 18/08/21 19:45 | Middlesbrough FC | Queens Park Rangers | 2-3 | 4 - 6 - 5 |
| 18/08/21 19:45 | 18/08/21 19:45 | Nottingham Forest | Blackburn Rovers | 1-2 | 5 - 6 - 5 |
| 18/08/21 19:45 | 18/08/21 19:45 | Hull City A.F.C. | Derby County | 0-1 | 4 - 7 - 7 |
| 18/08/21 19:45 | 18/08/21 19:45 | Birmingham City | AFC Bournemouth | 0-2 | 8 - 8 - 4 |
| 18/08/21 20:00 | 18/08/21 20:00 | West Bromwich Albion | Sheffield United | 4-0 | 3 - 10 - 10 |