Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/09/21 12:30 | 25/09/21 12:30 | Manchester United | Aston Villa | --- | 3 - 7 - 7 |
| 25/09/21 12:30 | 25/09/21 12:30 | Chelsea FC | Manchester City | --- | 4 - 5 - 5 |
| 25/09/21 15:00 | 25/09/21 15:00 | Leeds United | West Ham United | --- | 5 - 5 - 4 |
| 25/09/21 15:00 | 25/09/21 15:00 | Leicester City | Burnley FC | --- | 3 - 7 - 7 |
| 25/09/21 15:00 | 25/09/21 15:00 | Watford FC | Newcastle United | --- | 4 - 5 - 5 |
| 25/09/21 15:00 | 25/09/21 15:00 | Everton FC | Norwich City | --- | 3 - 7 - 7 |
| 25/09/21 17:30 | 25/09/21 17:30 | Brentford FC | Liverpool FC | --- | 7 - 7 - 3 |
| 26/09/21 14:00 | 26/09/21 14:00 | Southampton FC | Wolverhampton Wanderers | --- | 3 - 5 - 7 |
| 26/09/21 16:30 | 26/09/21 16:30 | Arsenal FC | Tottenham Hotspur | --- | 5 - 5 - 4 |
| 27/09/21 20:00 | 27/09/21 20:00 | Crystal Palace | Brighton and Hove Albion | --- | 4 - 5 - 5 |