| Date | Home | Away | Result |
|---|---|---|---|
| 01/06/18 20:00 | La Hoya Lorca | Sevilla Atlético | 2-1 |
| 02/06/18 19:30 | CD Teneriffa | Albacete Balompie | 1-1 |
| 02/06/18 19:30 | AD Alcorcon | CF Reus Deportiu | 3-0 |
| 02/06/18 19:30 | Real Oviedo | SD Huesca | 2-1 |
| 02/06/18 19:30 | Cordoba CF | Sporting Gijon | 3-0 |
| 02/06/18 19:30 | FC Barcelona B | Real Saragossa | 0-2 |
| 02/06/18 19:30 | CD Lugo | UD Almeria | 1-1 |
| 02/06/18 19:30 | Gimnastic de Tarragona | Rayo Vallecano | 2-0 |
| 02/06/18 19:30 | CD Numancia | Cultural y Deportiva Leonesa | 2-1 |
| 02/06/18 19:30 | Real Valladolid | CA Osasuna | 2-0 |
| 02/06/18 19:30 | FC Granada | FC Cadiz | 2-1 |