| Date | Home | Away | Result |
|---|---|---|---|
| 15/05/22 13:30 | FC Groningen | Cambuur-Leeuwarden | 2-3 |
| 15/05/22 13:30 | NEC Nijmwegen | Fortuna Sittard | 0-1 |
| 15/05/22 13:30 | SC Heerenveen | Go Ahead Eagles Deventer | 3-1 |
| 15/05/22 13:30 | Feyenoord Rotterdam | FC Twente Enschede | 1-2 |
| 15/05/22 13:30 | AZ Alkmaar | RKC Waalwijk | 1-3 |
| 15/05/22 13:30 | Heracles Almelo | Sparta Rotterdam | 1-3 |
| 15/05/22 13:30 | Vitesse Arnheim | Ajax Amsterdam | 2-2 |
| 15/05/22 13:30 | PEC Zwolle | PSV Eindhoven | 1-2 |
| 15/05/22 13:30 | Willem II Tilburg | FC Utrecht | 3-0 |