Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 05/11/21 19:30 | 05/11/21 19:20 | FSV Mainz 05 | Bor. Mönchengladbach | 1-1 | 3 - 5 points |
| 06/11/21 14:30 | 06/11/21 14:20 | VfB Stuttgart | Arminia Bielefeld | 0-1 | 3 - 5 points |
| 06/11/21 14:30 | 06/11/21 14:20 | VfL Wolfsburg | FC Augsburg | 1-0 | 3 - 5 points |
| 06/11/21 14:30 | 06/11/21 14:20 | FC Bayern Munich | SC Freiburg | 2-1 | 3 - 5 points |
| 06/11/21 14:30 | 06/11/21 14:20 | VfL Bochum | 1899 Hoffenheim | 2-0 | 3 - 5 points |
| 06/11/21 17:30 | 06/11/21 17:20 | RB Leipzig | Borussia Dortmund | 2-1 | 3 - 5 points |
| 07/11/21 14:30 | 07/11/21 14:20 | Hertha BSC | Bayer 04 Leverkusen | 1-1 | 3 - 5 points |
| 07/11/21 16:30 | 07/11/21 16:20 | 1. FC Köln | 1. FC Union Berlin | 2-2 | 3 - 5 points |
| 07/11/21 18:30 | 07/11/21 18:20 | SpVgg Greuther Fürth | Eintracht Frankfurt | 1-2 | 3 - 5 points |