| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 06/05/22 19:30 | 06/05/22 19:25 | VfL Bochum | Arminia Bielefeld | 2-1 | 2 - 4 points |
| 07/05/22 14:30 | 07/05/22 14:25 | 1899 Hoffenheim | Bayer 04 Leverkusen | 2-4 | 2 - 4 points |
| 07/05/22 14:30 | 07/05/22 14:25 | SC Freiburg | 1. FC Union Berlin | 1-4 | 2 - 4 points |
| 07/05/22 14:30 | 07/05/22 14:25 | SpVgg Greuther Fürth | Borussia Dortmund | 1-3 | 2 - 4 points |
| 07/05/22 14:30 | 07/05/22 14:25 | 1. FC Köln | VfL Wolfsburg | 0-1 | 2 - 4 points |
| 07/05/22 17:30 | 07/05/22 17:25 | Hertha BSC | FSV Mainz 05 | 1-2 | 2 - 4 points |
| 08/05/22 14:30 | 08/05/22 14:25 | Eintracht Frankfurt | Bor. Mönchengladbach | 1-1 | 2 - 4 points |
| 08/05/22 16:30 | 08/05/22 16:25 | FC Bayern Munich | VfB Stuttgart | 2-2 | 2 - 4 points |
| 08/05/22 18:30 | 08/05/22 18:25 | RB Leipzig | FC Augsburg | 4-0 | 2 - 4 points |
