| Date | Home | Away | Result |
|---|---|---|---|
| 15/10/21 19:30 | 1899 Hoffenheim | 1. FC Köln | 5-0 |
| 16/10/21 14:30 | 1. FC Union Berlin | VfL Wolfsburg | 2-0 |
| 16/10/21 14:30 | Eintracht Frankfurt | Hertha BSC | 1-2 |
| 16/10/21 14:30 | Borussia Dortmund | FSV Mainz 05 | 3-1 |
| 16/10/21 14:30 | SpVgg Greuther Fürth | VfL Bochum | 0-1 |
| 16/10/21 14:30 | SC Freiburg | RB Leipzig | 1-1 |
| 16/10/21 17:30 | Bor. Mönchengladbach | VfB Stuttgart | 1-1 |
| 17/10/21 14:30 | Bayer 04 Leverkusen | FC Bayern Munich | 1-5 |
| 17/10/21 16:30 | FC Augsburg | Arminia Bielefeld | 1-1 |