| Date | Home | Away | Result |
|---|---|---|---|
| 24/09/21 19:30 | SpVgg Greuther Fürth | FC Bayern Munich | 1-3 |
| 25/09/21 14:30 | Eintracht Frankfurt | 1. FC Köln | 1-1 |
| 25/09/21 14:30 | RB Leipzig | Hertha BSC | 6-0 |
| 25/09/21 14:30 | 1899 Hoffenheim | VfL Wolfsburg | 3-1 |
| 25/09/21 14:30 | 1. FC Union Berlin | Arminia Bielefeld | 1-0 |
| 25/09/21 14:30 | Bayer 04 Leverkusen | FSV Mainz 05 | 1-0 |
| 25/09/21 17:30 | Bor. Mönchengladbach | Borussia Dortmund | 1-0 |
| 26/09/21 14:30 | VfL Bochum | VfB Stuttgart | 0-0 |
| 26/09/21 16:30 | SC Freiburg | FC Augsburg | 3-0 |