| Date | Home | Away | Result |
|---|---|---|---|
| 17/09/21 19:30 | Hertha BSC | SpVgg Greuther Fürth | 2-1 |
| 18/09/21 14:30 | FC Bayern Munich | VfL Bochum | 7-0 |
| 18/09/21 14:30 | Arminia Bielefeld | 1899 Hoffenheim | 0-0 |
| 18/09/21 14:30 | FC Augsburg | Bor. Mönchengladbach | 1-0 |
| 18/09/21 14:30 | FSV Mainz 05 | SC Freiburg | 0-0 |
| 18/09/21 17:30 | 1. FC Köln | RB Leipzig | 1-1 |
| 19/09/21 14:30 | VfB Stuttgart | Bayer 04 Leverkusen | 1-3 |
| 19/09/21 16:30 | Borussia Dortmund | 1. FC Union Berlin | 4-2 |
| 19/09/21 18:30 | VfL Wolfsburg | Eintracht Frankfurt | 1-1 |