| Date | Home | Away | Result |
|---|---|---|---|
| 16/04/22 14:30 | FC Augsburg | Hertha BSC | 0-1 |
| 16/04/22 14:30 | FSV Mainz 05 | VfB Stuttgart | 0-0 |
| 16/04/22 14:30 | SC Freiburg | VfL Bochum | 3-0 |
| 16/04/22 14:30 | Borussia Dortmund | VfL Wolfsburg | 6-1 |
| 16/04/22 17:30 | Bor. Mönchengladbach | 1. FC Köln | 1-3 |
| 17/04/22 14:30 | Arminia Bielefeld | FC Bayern Munich | 0-3 |
| 17/04/22 16:30 | 1899 Hoffenheim | SpVgg Greuther Fürth | 0-0 |
| 17/04/22 16:30 | 1. FC Union Berlin | Eintracht Frankfurt | 2-0 |
| 17/04/22 18:30 | Bayer 04 Leverkusen | RB Leipzig | 0-1 |