| Date | Home | Away | Result |
|---|---|---|---|
| 27/08/21 19:30 | Borussia Dortmund | 1899 Hoffenheim | 3-2 |
| 28/08/21 14:30 | FC Augsburg | Bayer 04 Leverkusen | 1-4 |
| 28/08/21 14:30 | FSV Mainz 05 | SpVgg Greuther Fürth | 3-0 |
| 28/08/21 14:30 | VfB Stuttgart | SC Freiburg | 2-3 |
| 28/08/21 14:30 | 1. FC Köln | VfL Bochum | 2-1 |
| 28/08/21 14:30 | Arminia Bielefeld | Eintracht Frankfurt | 1-1 |
| 28/08/21 17:30 | FC Bayern Munich | Hertha BSC | 5-0 |
| 29/08/21 14:30 | 1. FC Union Berlin | Bor. Mönchengladbach | 2-1 |
| 29/08/21 16:30 | VfL Wolfsburg | RB Leipzig | 1-0 |