| Date | Home | Away | Result |
|---|---|---|---|
| 04/03/22 19:30 | Arminia Bielefeld | FC Augsburg | 0-1 |
| 05/03/22 14:30 | Hertha BSC | Eintracht Frankfurt | 1-4 |
| 05/03/22 14:30 | FC Bayern Munich | Bayer 04 Leverkusen | 1-1 |
| 05/03/22 14:30 | VfL Wolfsburg | 1. FC Union Berlin | 1-0 |
| 05/03/22 14:30 | RB Leipzig | SC Freiburg | 1-1 |
| 05/03/22 14:30 | VfL Bochum | SpVgg Greuther Fürth | 2-1 |
| 05/03/22 17:30 | VfB Stuttgart | Bor. Mönchengladbach | 3-2 |
| 06/03/22 16:30 | 1. FC Köln | 1899 Hoffenheim | 0-1 |
| 16/03/22 17:30 | FSV Mainz 05 | Borussia Dortmund | 0-1 |