| Date | Home | Away | Result |
|---|---|---|---|
| 25/02/22 19:30 | 1899 Hoffenheim | VfB Stuttgart | 2-1 |
| 26/02/22 14:30 | SC Freiburg | Hertha BSC | 3-0 |
| 26/02/22 14:30 | Bor. Mönchengladbach | VfL Wolfsburg | 2-2 |
| 26/02/22 14:30 | 1. FC Union Berlin | FSV Mainz 05 | 3-1 |
| 26/02/22 14:30 | Bayer 04 Leverkusen | Arminia Bielefeld | 3-0 |
| 26/02/22 14:30 | SpVgg Greuther Fürth | 1. FC Köln | 1-1 |
| 26/02/22 17:30 | Eintracht Frankfurt | FC Bayern Munich | 0-1 |
| 27/02/22 14:30 | VfL Bochum | RB Leipzig | 0-1 |
| 27/02/22 16:30 | FC Augsburg | Borussia Dortmund | 1-1 |