| Date | Home | Away | Result |
|---|---|---|---|
| 14/01/22 19:30 | Borussia Dortmund | SC Freiburg | 5-1 |
| 15/01/22 14:30 | FSV Mainz 05 | VfL Bochum | 1-0 |
| 15/01/22 14:30 | VfB Stuttgart | RB Leipzig | 0-2 |
| 15/01/22 14:30 | 1. FC Union Berlin | 1899 Hoffenheim | 2-1 |
| 15/01/22 14:30 | VfL Wolfsburg | Hertha BSC | 0-0 |
| 15/01/22 14:30 | 1. FC Köln | FC Bayern Munich | 0-4 |
| 15/01/22 17:30 | Bor. Mönchengladbach | Bayer 04 Leverkusen | 1-2 |
| 16/01/22 14:30 | FC Augsburg | Eintracht Frankfurt | 1-1 |
| 16/01/22 16:30 | Arminia Bielefeld | SpVgg Greuther Fürth | 2-2 |