| Date | Home | Away | Result |
|---|---|---|---|
| 17/12/21 19:30 | FC Bayern Munich | VfL Wolfsburg | 4-0 |
| 18/12/21 14:30 | 1899 Hoffenheim | Bor. Mönchengladbach | 1-1 |
| 18/12/21 14:30 | Eintracht Frankfurt | FSV Mainz 05 | 1-0 |
| 18/12/21 14:30 | RB Leipzig | Arminia Bielefeld | 0-2 |
| 18/12/21 14:30 | SpVgg Greuther Fürth | FC Augsburg | 0-0 |
| 18/12/21 14:30 | VfL Bochum | 1. FC Union Berlin | 0-1 |
| 18/12/21 17:30 | Hertha BSC | Borussia Dortmund | 3-2 |
| 19/12/21 14:30 | SC Freiburg | Bayer 04 Leverkusen | 2-1 |
| 19/12/21 16:30 | 1. FC Köln | VfB Stuttgart | 1-0 |