| Date | Home | Away | Result |
|---|---|---|---|
| 10/12/21 19:30 | 1. FC Köln | FC Augsburg | 0-2 |
| 11/12/21 14:30 | RB Leipzig | Bor. Mönchengladbach | 4-1 |
| 11/12/21 14:30 | FC Bayern Munich | FSV Mainz 05 | 2-1 |
| 11/12/21 14:30 | VfL Bochum | Borussia Dortmund | 1-1 |
| 11/12/21 14:30 | Hertha BSC | Arminia Bielefeld | 2-0 |
| 11/12/21 14:30 | SC Freiburg | 1899 Hoffenheim | 1-2 |
| 11/12/21 17:30 | VfL Wolfsburg | VfB Stuttgart | 0-2 |
| 12/12/21 14:30 | SpVgg Greuther Fürth | 1. FC Union Berlin | 1-0 |
| 12/12/21 16:30 | Eintracht Frankfurt | Bayer 04 Leverkusen | 5-2 |