| Date | Home | Away | Result |
|---|---|---|---|
| 08/11/22 17:30 | VfL Wolfsburg | Borussia Dortmund | 2-0 |
| 08/11/22 19:30 | VfL Bochum | Bor. Mönchengladbach | 2-1 |
| 08/11/22 19:30 | VfB Stuttgart | Hertha BSC | 2-1 |
| 08/11/22 19:30 | FC Bayern Munich | Werder Bremen | 6-1 |
| 09/11/22 17:30 | 1. FC Köln | Bayer 04 Leverkusen | 1-2 |
| 09/11/22 19:30 | 1. FC Union Berlin | FC Augsburg | 2-2 |
| 09/11/22 19:30 | Eintracht Frankfurt | 1899 Hoffenheim | 4-2 |
| 09/11/22 19:30 | RB Leipzig | SC Freiburg | 3-1 |
| 09/11/22 19:30 | FC Schalke 04 | FSV Mainz 05 | 1-0 |