| Date | Home | Away | Result |
|---|---|---|---|
| 03/12/21 19:30 | 1. FC Union Berlin | RB Leipzig | 2-1 |
| 04/12/21 14:30 | FSV Mainz 05 | VfL Wolfsburg | 3-0 |
| 04/12/21 14:30 | 1899 Hoffenheim | Eintracht Frankfurt | 3-2 |
| 04/12/21 14:30 | Bayer 04 Leverkusen | SpVgg Greuther Fürth | 7-1 |
| 04/12/21 14:30 | Arminia Bielefeld | 1. FC Köln | 1-1 |
| 04/12/21 14:30 | FC Augsburg | VfL Bochum | 2-3 |
| 04/12/21 17:30 | Borussia Dortmund | FC Bayern Munich | 2-3 |
| 05/12/21 14:30 | VfB Stuttgart | Hertha BSC | 2-2 |
| 05/12/21 16:30 | Bor. Mönchengladbach | SC Freiburg | 0-6 |