| Date | Home | Away | Result |
|---|---|---|---|
| 04/11/22 19:30 | Bor. Mönchengladbach | VfB Stuttgart | 3-1 |
| 05/11/22 14:30 | Borussia Dortmund | VfL Bochum | 3-0 |
| 05/11/22 14:30 | 1899 Hoffenheim | RB Leipzig | 1-3 |
| 05/11/22 14:30 | FSV Mainz 05 | VfL Wolfsburg | 0-3 |
| 05/11/22 14:30 | FC Augsburg | Eintracht Frankfurt | 1-2 |
| 05/11/22 14:30 | Hertha BSC | FC Bayern Munich | 2-3 |
| 05/11/22 17:30 | Werder Bremen | FC Schalke 04 | 2-1 |
| 06/11/22 14:30 | Bayer 04 Leverkusen | 1. FC Union Berlin | 5-0 |
| 06/11/22 16:30 | SC Freiburg | 1. FC Köln | 2-0 |