| Date | Home | Away | Result |
|---|---|---|---|
| 05/11/21 19:30 | FSV Mainz 05 | Bor. Mönchengladbach | 1-1 |
| 06/11/21 14:30 | VfB Stuttgart | Arminia Bielefeld | 0-1 |
| 06/11/21 14:30 | VfL Wolfsburg | FC Augsburg | 1-0 |
| 06/11/21 14:30 | FC Bayern Munich | SC Freiburg | 2-1 |
| 06/11/21 14:30 | VfL Bochum | 1899 Hoffenheim | 2-0 |
| 06/11/21 17:30 | RB Leipzig | Borussia Dortmund | 2-1 |
| 07/11/21 14:30 | Hertha BSC | Bayer 04 Leverkusen | 1-1 |
| 07/11/21 16:30 | 1. FC Köln | 1. FC Union Berlin | 2-2 |
| 07/11/21 18:30 | SpVgg Greuther Fürth | Eintracht Frankfurt | 1-2 |