| Date | Home | Away | Result |
|---|---|---|---|
| 29/10/21 19:30 | 1899 Hoffenheim | Hertha BSC | 2-0 |
| 30/10/21 14:30 | Arminia Bielefeld | FSV Mainz 05 | 1-2 |
| 30/10/21 14:30 | SC Freiburg | SpVgg Greuther Fürth | 3-1 |
| 30/10/21 14:30 | 1. FC Union Berlin | FC Bayern Munich | 2-5 |
| 30/10/21 14:30 | Bayer 04 Leverkusen | VfL Wolfsburg | 0-2 |
| 30/10/21 14:30 | Borussia Dortmund | 1. FC Köln | 2-0 |
| 30/10/21 17:30 | Eintracht Frankfurt | RB Leipzig | 1-1 |
| 31/10/21 14:30 | FC Augsburg | VfB Stuttgart | 4-1 |
| 31/10/21 16:30 | Bor. Mönchengladbach | VfL Bochum | 2-1 |