| Date | Home | Away | Result |
|---|---|---|---|
| 13/08/21 19:30 | Bor. Mönchengladbach | FC Bayern Munich | 1-1 |
| 14/08/21 14:30 | VfL Wolfsburg | VfL Bochum | 1-0 |
| 14/08/21 14:30 | 1. FC Union Berlin | Bayer 04 Leverkusen | 1-1 |
| 14/08/21 14:30 | VfB Stuttgart | SpVgg Greuther Fürth | 5-1 |
| 14/08/21 14:30 | FC Augsburg | 1899 Hoffenheim | 0-4 |
| 14/08/21 14:30 | Arminia Bielefeld | SC Freiburg | 0-0 |
| 14/08/21 17:30 | Borussia Dortmund | Eintracht Frankfurt | 5-2 |
| 15/08/21 14:30 | FSV Mainz 05 | RB Leipzig | 1-0 |
| 15/08/21 16:30 | 1. FC Köln | Hertha BSC | 3-1 |