| Date | Home | Away | Result |
|---|---|---|---|
| 12/12/25 19:30 | Palermo FC | Sampdoria Genua | 1-0 |
| 13/12/25 14:00 | Juve Stabia | FC Empoli | 2-0 |
| 13/12/25 14:00 | AC Reggiana 1919 | Padova Calcio | 1-2 |
| 13/12/25 14:00 | Spezia Calcio | Modena FC | 0-2 |
| 13/12/25 14:00 | FC Südtirol | SSC Bari | 0-0 |
| 13/12/25 14:00 | FC Venice | AC Monza | 2-0 |
| 13/12/25 16:15 | US Catanzaro 1929 | US Avellino | 1-0 |
| 13/12/25 18:30 | FC Cesena | Mantova 1911 | 3-2 |
| 14/12/25 14:00 | Carrarese Calcio 1908 | Virtus Entella | --- |
| 14/12/25 16:15 | Pescara Calcio | Frosinone Calcio | --- |