| Date | Home | Away | Result |
|---|---|---|---|
| 13/09/25 14:00 | Cagliari Calcio | Parma Calcio 1913 | 2-0 |
| 13/09/25 17:00 | Juventus Turin | Inter Milan | 4-3 |
| 13/09/25 19:45 | Fiorentina | SSC Napoli | 1-3 |
| 14/09/25 11:30 | AS Roma | FC Turin | 0-1 |
| 14/09/25 14:00 | Atalanta Bergamo | US Lecce | 4-1 |
| 14/09/25 14:00 | Pisa Sporting Club | Udinese Calcio | 0-1 |
| 14/09/25 17:00 | Sassuolo Calcio | Lazio Rom | 1-0 |
| 14/09/25 19:45 | AC Milan | FC Bologna | 1-0 |
| 15/09/25 17:30 | Hellas Verona | US Cremonese | --- |
| 15/09/25 19:45 | Como Calcio | Genua CFC | --- |