| Date | Home | Away | Result |
|---|---|---|---|
| 04/12/22 00:00 | Detroit Red Wings | Vegas Golden Knights | 1-4 |
| 04/12/22 00:00 | Philadelphia Flyers | New Jersey Devils | 2-3 |
| 04/12/22 00:00 | Edmonton Oilers | Montréal Canadiens | 5-3 |
| 04/12/22 00:00 | Ottawa Senators | San Jose Sharks | 5-2 |
| 04/12/22 00:00 | Boston Bruins | Colorado Avalanche | 5-1 |
| 04/12/22 00:00 | Tampa Bay Lightning | Toronto Maple Leafs | 4-3OT |
| 04/12/22 00:00 | Pittsburgh Penguins | St. Louis Blues | 6-2 |
| 04/12/22 00:30 | New York Rangers | Chicago Blackhawks | 2-5 |
| 04/12/22 03:00 | Calgary Flames | Washington Capitals | 5-2 |
| 04/12/22 03:00 | Vancouver Canucks | Arizona Coyotes | 3-2OT |
| 04/12/22 03:00 | Seattle Kraken | Florida Panthers | 1-5 |
| 04/12/22 03:30 | Los Angeles Kings | Carolina Hurricanes | 2-4 |
| 04/12/22 20:00 | Dallas Stars | Minnesota Wild | 5-6a.pen. |
| 04/12/22 20:00 | Winnipeg Jets | Anaheim Ducks | 5-2 |