| Date | Home | Away | Result |
|---|---|---|---|
| 21/10/22 01:15 | Arizona Cardinals | New Orleans Saints | 42-34 |
| 23/10/22 18:00 | Washington Commanders | Green Bay Packers | 23-21 |
| 23/10/22 18:00 | Baltimore Ravens | Cleveland Browns | 23-20 |
| 23/10/22 18:00 | Tennessee Titans | Indianapolis Colts | 19-10 |
| 23/10/22 18:00 | Dallas Cowboys | Detroit Lions | 24-6 |
| 23/10/22 18:00 | Carolina Panthers | Tampa Bay Buccaneers | 21-3 |
| 23/10/22 18:00 | Cincinnati Bengals | Atlanta Falcons | 35-17 |
| 23/10/22 18:00 | Jacksonville Jaguars | New York Giants | 17-23 |
| 23/10/22 21:05 | Las Vegas Raiders | Houston Texans | 38-20 |
| 23/10/22 21:05 | Denver Broncos | New York Jets | 9-16 |
| 23/10/22 21:25 | Los Angeles Chargers | Seattle Seahawks | 23-37 |
| 23/10/22 21:25 | San Francisco 49ers | Kansas City Chiefs | 23-44 |
| 24/10/22 01:20 | Miami Dolphins | Pittsburgh Steelers | 16-10 |
| 25/10/22 01:15 | New England Patriots | Chicago Bears | 14-33 |