| Date | Home | Away | Result |
|---|---|---|---|
| 23/12/22 01:15 | New York Jets | Jacksonville Jaguars | 3-19 |
| 24/12/22 18:00 | Chicago Bears | Buffalo Bills | 13-35 |
| 24/12/22 18:00 | Minnesota Vikings | New York Giants | 27-24 |
| 24/12/22 18:00 | Carolina Panthers | Detroit Lions | 37-23 |
| 24/12/22 18:00 | Baltimore Ravens | Atlanta Falcons | 17-9 |
| 24/12/22 18:00 | New England Patriots | Cincinnati Bengals | 18-22 |
| 24/12/22 18:00 | Cleveland Browns | New Orleans Saints | 10-17 |
| 24/12/22 18:00 | Kansas City Chiefs | Seattle Seahawks | 24-10 |
| 24/12/22 19:02 | Tennessee Titans | Houston Texans | 14-19 |
| 24/12/22 21:05 | San Francisco 49ers | Washington Commanders | 37-20 |
| 24/12/22 21:25 | Dallas Cowboys | Philadelphia Eagles | 40-34 |
| 25/12/22 01:15 | Pittsburgh Steelers | Las Vegas Raiders | 13-10 |
| 25/12/22 18:00 | Miami Dolphins | Green Bay Packers | 20-26 |
| 25/12/22 21:30 | Los Angeles Rams | Denver Broncos | 51-14 |
| 26/12/22 01:20 | Arizona Cardinals | Tampa Bay Buccaneers | 16-19OT |
| 27/12/22 01:15 | Indianapolis Colts | Los Angeles Chargers | 3-20 |