| Date | Home | Away | Result |
|---|---|---|---|
| 09/12/22 01:15 | Los Angeles Rams | Las Vegas Raiders | 17-16 |
| 11/12/22 18:00 | Pittsburgh Steelers | Baltimore Ravens | 14-16 |
| 11/12/22 18:00 | Tennessee Titans | Jacksonville Jaguars | 22-36 |
| 11/12/22 18:00 | New York Giants | Philadelphia Eagles | 22-48 |
| 11/12/22 18:00 | Cincinnati Bengals | Cleveland Browns | 23-10 |
| 11/12/22 18:00 | Buffalo Bills | New York Jets | 20-12 |
| 11/12/22 18:00 | Detroit Lions | Minnesota Vikings | 34-23 |
| 11/12/22 18:00 | Dallas Cowboys | Houston Texans | 27-23 |
| 11/12/22 21:05 | Denver Broncos | Kansas City Chiefs | 28-34 |
| 11/12/22 21:25 | Seattle Seahawks | Carolina Panthers | 24-30 |
| 11/12/22 21:25 | San Francisco 49ers | Tampa Bay Buccaneers | 35-7 |
| 12/12/22 01:20 | Los Angeles Chargers | Miami Dolphins | 23-17 |
| 13/12/22 01:15 | Arizona Cardinals | New England Patriots | 13-27 |