| Date | Home | Away | Result |
|---|---|---|---|
| 24/11/22 17:30 | Detroit Lions | Buffalo Bills | 25-28 |
| 24/11/22 21:30 | Dallas Cowboys | New York Giants | 28-20 |
| 25/11/22 01:20 | Minnesota Vikings | New England Patriots | 33-26 |
| 27/11/22 18:00 | New York Jets | Chicago Bears | 31-10 |
| 27/11/22 18:00 | Washington Commanders | Atlanta Falcons | 19-13 |
| 27/11/22 18:00 | Carolina Panthers | Denver Broncos | 23-10 |
| 27/11/22 18:00 | Jacksonville Jaguars | Baltimore Ravens | 28-27 |
| 27/11/22 18:00 | Miami Dolphins | Houston Texans | 30-15 |
| 27/11/22 18:00 | Cleveland Browns | Tampa Bay Buccaneers | 23-17OT |
| 27/11/22 18:00 | Tennessee Titans | Cincinnati Bengals | 16-20 |
| 27/11/22 21:05 | Seattle Seahawks | Las Vegas Raiders | 34-40OT |
| 27/11/22 21:05 | Arizona Cardinals | Los Angeles Chargers | 24-25 |
| 27/11/22 21:25 | Kansas City Chiefs | Los Angeles Rams | 26-10 |
| 27/11/22 21:25 | San Francisco 49ers | New Orleans Saints | 13-0 |
| 28/11/22 01:20 | Philadelphia Eagles | Green Bay Packers | 40-33 |
| 29/11/22 01:15 | Indianapolis Colts | Pittsburgh Steelers | 17-24 |