| Date | Home | Away | Result |
|---|---|---|---|
| 18/11/22 01:15 | Green Bay Packers | Tennessee Titans | 17-27 |
| 20/11/22 18:00 | Atlanta Falcons | Chicago Bears | 27-24 |
| 20/11/22 18:00 | Buffalo Bills | Cleveland Browns | 31-23 |
| 20/11/22 18:00 | New York Giants | Detroit Lions | 18-31 |
| 20/11/22 18:00 | New Orleans Saints | Los Angeles Rams | 27-20 |
| 20/11/22 18:00 | Indianapolis Colts | Philadelphia Eagles | 16-17 |
| 20/11/22 18:00 | New England Patriots | New York Jets | 10-3 |
| 20/11/22 18:00 | Baltimore Ravens | Carolina Panthers | 13-3 |
| 20/11/22 18:00 | Houston Texans | Washington Commanders | 10-23 |
| 20/11/22 21:05 | Denver Broncos | Las Vegas Raiders | 16-22OT |
| 20/11/22 21:25 | Pittsburgh Steelers | Cincinnati Bengals | 30-37 |
| 20/11/22 21:25 | Minnesota Vikings | Dallas Cowboys | 3-40 |
| 21/11/22 01:20 | Los Angeles Chargers | Kansas City Chiefs | 27-30 |
| 22/11/22 01:15 | Arizona Cardinals | San Francisco 49ers | 10-38 |