| Date | Home | Away | Result |
|---|---|---|---|
| 11/11/22 01:15 | Carolina Panthers | Atlanta Falcons | 25-15 |
| 13/11/22 14:30 | Tampa Bay Buccaneers | Seattle Seahawks | 21-16 |
| 13/11/22 18:00 | Kansas City Chiefs | Jacksonville Jaguars | 27-17 |
| 13/11/22 18:00 | Chicago Bears | Detroit Lions | 30-31 |
| 13/11/22 18:00 | Pittsburgh Steelers | New Orleans Saints | 20-10 |
| 13/11/22 18:00 | Miami Dolphins | Cleveland Browns | 39-17 |
| 13/11/22 18:00 | Tennessee Titans | Denver Broncos | 17-10 |
| 13/11/22 18:00 | New York Giants | Houston Texans | 24-16 |
| 13/11/22 18:00 | Buffalo Bills | Minnesota Vikings | 30-33OT |
| 13/11/22 21:05 | Las Vegas Raiders | Indianapolis Colts | 20-25 |
| 13/11/22 21:25 | Green Bay Packers | Dallas Cowboys | 31-28OT |
| 13/11/22 21:25 | Los Angeles Rams | Arizona Cardinals | 17-27 |
| 14/11/22 01:20 | San Francisco 49ers | Los Angeles Chargers | 22-16 |
| 15/11/22 01:15 | Philadelphia Eagles | Washington Commanders | 21-32 |