| Date | Home | Away | Result |
|---|---|---|---|
| 12/09/25 01:15 | Green Bay Packers | Washington Commanders | 27-18 |
| 14/09/25 18:00 | Detroit Lions | Chicago Bears | 52-21 |
| 14/09/25 18:00 | Cincinnati Bengals | Jacksonville Jaguars | 31-27 |
| 14/09/25 18:00 | Dallas Cowboys | New York Giants | 40-37OT |
| 14/09/25 18:00 | New Orleans Saints | San Francisco 49ers | 21-26 |
| 14/09/25 18:00 | Baltimore Ravens | Cleveland Browns | 41-17 |
| 14/09/25 18:00 | Tennessee Titans | Los Angeles Rams | 19-33 |
| 14/09/25 18:00 | Pittsburgh Steelers | Seattle Seahawks | 17-31 |
| 14/09/25 18:00 | New York Jets | Buffalo Bills | 10-30 |
| 14/09/25 18:00 | Miami Dolphins | New England Patriots | 27-33 |
| 14/09/25 21:05 | Indianapolis Colts | Denver Broncos | 29-28 |
| 14/09/25 21:05 | Arizona Cardinals | Carolina Panthers | 27-22 |
| 14/09/25 21:25 | Kansas City Chiefs | Philadelphia Eagles | 17-20 |
| 15/09/25 01:20 | Minnesota Vikings | Atlanta Falcons | 6-22 |
| 16/09/25 00:00 | Houston Texans | Tampa Bay Buccaneers | --- |
| 16/09/25 03:00 | Las Vegas Raiders | Los Angeles Chargers | --- |