| Date | Home | Away | Result |
|---|---|---|---|
| 02/04/23 00:30 | Philadelphia Union | Sporting Kansas City | 0-0 |
| 02/04/23 00:30 | New England Revolution | New York City FC | 1-1 |
| 02/04/23 00:30 | Orlando City | Nashville SC | 0-2 |
| 02/04/23 00:30 | Columbus Crew | Real Salt Lake | 4-0 |
| 02/04/23 00:30 | Los Angeles Galaxy | Seattle Sounders | 1-2 |
| 02/04/23 00:30 | Atlanta United FC | New York Red Bulls | 1-0 |
| 02/04/23 00:30 | Cincinnati FC | Inter Miami CF | 1-0 |
| 02/04/23 00:30 | Toronto FC | Charlotte FC | 2-2 |
| 02/04/23 01:30 | FC Dallas | Portland Timbers | 1-1 |
| 02/04/23 01:30 | Chicago Fire | D.C. United | 0-0 |
| 02/04/23 01:30 | St. Louis City SC | Minnesota United FC | 0-1 |
| 02/04/23 02:30 | Colorado Rapids | Los Angeles FC | 0-0 |
| 02/04/23 03:30 | Vancouver Whitecaps | CF Montreal | 5-0 |
| 02/04/23 03:30 | San Jose Earthquakes | Houston Dynamo | 2-1 |