| Date | Home | Away | Result |
|---|---|---|---|
| 01/10/23 00:30 | Toronto FC | Cincinnati FC | 2-3 |
| 01/10/23 00:30 | Orlando City | CF Montreal | 3-0 |
| 01/10/23 00:30 | New York Red Bulls | Chicago Fire | 0-1 |
| 01/10/23 00:30 | Inter Miami CF | New York City FC | 1-1 |
| 01/10/23 00:30 | New England Revolution | Charlotte FC | 2-1 |
| 01/10/23 00:30 | Columbus Crew | Philadelphia Union | 1-1 |
| 01/10/23 01:30 | Houston Dynamo | FC Dallas | 0-0 |
| 01/10/23 01:30 | Nashville SC | Seattle Sounders | 0-0 |
| 01/10/23 01:30 | Minnesota United FC | San Jose Earthquakes | 1-1 |
| 01/10/23 01:30 | St. Louis City SC | Sporting Kansas City | 4-1 |
| 01/10/23 02:30 | Colorado Rapids | Austin FC | 1-0 |
| 01/10/23 03:30 | Vancouver Whitecaps | D.C. United | 2-2 |
| 01/10/23 03:30 | Los Angeles Galaxy | Portland Timbers | 3-3 |
| 02/10/23 01:00 | Los Angeles FC | Real Salt Lake | 0-1 |