| Date | Home | Away | Result |
|---|---|---|---|
| 28/05/23 00:30 | Orlando City | Atlanta United FC | 1-1 |
| 28/05/23 00:30 | New York City FC | Philadelphia Union | 1-3 |
| 28/05/23 00:30 | New England Revolution | Chicago Fire | 3-3 |
| 28/05/23 00:30 | Toronto FC | D.C. United | 2-1 |
| 28/05/23 00:30 | CF Montreal | Inter Miami CF | 1-0 |
| 28/05/23 01:30 | Minnesota United FC | Real Salt Lake | 1-1 |
| 28/05/23 01:30 | Houston Dynamo | Austin FC | 2-1 |
| 28/05/23 01:30 | St. Louis City SC | Vancouver Whitecaps | 3-1 |
| 28/05/23 02:30 | Colorado Rapids | Cincinnati FC | 0-1 |
| 28/05/23 03:30 | Los Angeles Galaxy | Charlotte FC | 0-1 |
| 28/05/23 03:30 | Seattle Sounders | New York Red Bulls | 1-0 |
| 28/05/23 03:30 | San Jose Earthquakes | FC Dallas | 1-1 |
| 28/05/23 20:00 | Sporting Kansas City | Portland Timbers | 4-1 |
| 29/05/23 01:30 | Nashville SC | Columbus Crew | 3-1 |