| Date | Home | Away | Result |
|---|---|---|---|
| 21/05/23 00:30 | Inter Miami CF | Orlando City | 1-3 |
| 21/05/23 00:30 | Philadelphia Union | New England Revolution | 3-0 |
| 21/05/23 00:30 | Cincinnati FC | Columbus Crew | 3-2 |
| 21/05/23 00:30 | D.C. United | Los Angeles Galaxy | 3-0 |
| 21/05/23 00:30 | Charlotte FC | Nashville SC | 1-2 |
| 21/05/23 00:30 | New York Red Bulls | CF Montreal | 2-1 |
| 21/05/23 01:30 | Chicago Fire | Atlanta United FC | 3-3 |
| 21/05/23 01:30 | FC Dallas | Houston Dynamo | 1-1 |
| 21/05/23 01:30 | Austin FC | Toronto FC | 1-0 |
| 21/05/23 02:30 | Colorado Rapids | Real Salt Lake | 2-3 |
| 21/05/23 02:30 | St. Louis City SC | Sporting Kansas City | 4-0 |
| 21/05/23 03:30 | Vancouver Whitecaps | Seattle Sounders | 2-0 |
| 21/05/23 03:30 | Los Angeles FC | San Jose Earthquakes | 2-1 |
| 21/05/23 03:30 | Portland Timbers | Minnesota United FC | 0-1 |