| Date | Home | Away | Result |
|---|---|---|---|
| 18/05/23 00:30 | Cincinnati FC | CF Montreal | 3-0 |
| 18/05/23 00:30 | Toronto FC | New York Red Bulls | 0-0 |
| 18/05/23 00:30 | Orlando City | New York City FC | 1-1 |
| 18/05/23 00:30 | Philadelphia Union | D.C. United | 0-0 |
| 18/05/23 00:30 | Charlotte FC | Chicago Fire | 2-1 |
| 18/05/23 00:30 | Columbus Crew | Los Angeles Galaxy | 2-0 |
| 18/05/23 00:30 | Atlanta United FC | Colorado Rapids | 4-0 |
| 18/05/23 01:30 | FC Dallas | Vancouver Whitecaps | 2-1 |
| 18/05/23 01:30 | Minnesota United FC | Houston Dynamo | 1-0 |
| 18/05/23 01:30 | Nashville SC | Inter Miami CF | 2-1 |
| 18/05/23 02:30 | Real Salt Lake | Portland Timbers | 0-0 |
| 18/05/23 03:30 | Seattle Sounders | Austin FC | 1-2 |
| 18/05/23 03:30 | Los Angeles FC | Sporting Kansas City | 1-1 |