| Date | Home | Away | Result |
|---|---|---|---|
| 13/05/23 18:00 | Chicago Fire | St. Louis City SC | 1-0 |
| 14/05/23 00:30 | Columbus Crew | Orlando City | 2-2 |
| 14/05/23 00:30 | Atlanta United FC | Charlotte FC | 1-3 |
| 14/05/23 00:30 | CF Montreal | Toronto FC | 2-0 |
| 14/05/23 00:30 | D.C. United | Nashville SC | 1-1 |
| 14/05/23 00:30 | Inter Miami CF | New England Revolution | 2-1 |
| 14/05/23 00:30 | New York Red Bulls | New York City FC | 1-0 |
| 14/05/23 01:30 | Sporting Kansas City | Minnesota United FC | 3-0 |
| 14/05/23 01:30 | Houston Dynamo | Seattle Sounders | 0-1 |
| 14/05/23 01:30 | Austin FC | FC Dallas | 0-1 |
| 14/05/23 02:30 | Colorado Rapids | Philadelphia Union | 1-2 |
| 14/05/23 02:30 | Real Salt Lake | Los Angeles FC | 0-3 |
| 14/05/23 03:30 | Portland Timbers | Vancouver Whitecaps | 3-1 |
| 15/05/23 02:30 | Los Angeles Galaxy | San Jose Earthquakes | 2-1 |