| Date | Home | Away | Result |
|---|---|---|---|
| 06/01/23 20:00 | Manchester United | Everton FC | 3-1 |
| 07/01/23 12:30 | Preston North End | Huddersfield Town | 3-1 |
| 07/01/23 12:30 | Reading FC | Watford FC | 2-0 |
| 07/01/23 12:30 | Crystal Palace | Southampton FC | 1-2 |
| 07/01/23 12:30 | Tottenham Hotspur | FC Portsmouth | 1-0 |
| 07/01/23 12:30 | FC Gillingham | Leicester City | 0-1 |
| 07/01/23 15:00 | Middlesbrough FC | Brighton and Hove Albion | 1-5 |
| 07/01/23 15:00 | FC Chesterfield | West Bromwich Albion | 3-3 |
| 07/01/23 15:00 | Ipswich Town | Rotherham United | 4-1 |
| 07/01/23 15:00 | Shrewsbury Town | AFC Sunderland | 1-2 |
| 07/01/23 15:00 | Millwall FC | Sheffield United | 0-2 |
| 07/01/23 15:00 | Hull City A.F.C. | Fulham FC | 0-2 |
| 07/01/23 15:00 | FC Blackpool | Nottingham Forest | 4-1 |
| 07/01/23 15:00 | Fleetwood Town | Queens Park Rangers | 2-1 |
| 07/01/23 15:00 | AFC Bournemouth | Burnley FC | 2-4 |
| 07/01/23 15:00 | Boreham Wood | Accrington Stanley | 1-1 |
| 07/01/23 17:30 | Grimsby Town | Burton Albion | 1-0 |
| 07/01/23 17:30 | Luton Town | Wigan Athletic | 1-1 |
| 07/01/23 17:30 | Coventry City | AFC Wrexham | 3-4 |
| 07/01/23 17:30 | Brentford FC | West Ham United | 0-1 |
| 07/01/23 18:00 | Sheffield Wednesday | Newcastle United | 2-1 |
| 07/01/23 20:00 | Liverpool FC | Wolverhampton Wanderers | 2-2 |
| 08/01/23 12:30 | Bristol City | Swansea City | 1-1 |
| 08/01/23 12:30 | Derby County | Barnsley FC | 3-0 |
| 08/01/23 14:00 | Hartlepool United | Stoke City | 0-3 |
| 08/01/23 14:00 | Norwich City | Blackburn Rovers | 0-1 |
| 08/01/23 14:00 | Cardiff City | Leeds United | 2-2 |
| 08/01/23 14:00 | Stockport County | FC Walsall | 1-2 |
| 08/01/23 16:30 | Manchester City | Chelsea FC | 4-0 |
| 08/01/23 16:30 | Aston Villa | Stevenage FC | 1-2 |
| 09/01/23 20:00 | Oxford United | Arsenal FC | 0-3 |
| 17/01/23 19:45 | Forest Green Rovers | Birmingham City | 1-2 |
| 17/01/23 19:45 | Wigan Athletic | Luton Town | 1-2 |
| 17/01/23 19:45 | Wolverhampton Wanderers | Liverpool FC | 0-1 |
| 17/01/23 19:45 | Swansea City | Bristol City | 1-2a.e.t |
| 17/01/23 20:00 | West Bromwich Albion | FC Chesterfield | 4-0 |
| 18/01/23 19:45 | Leeds United | Cardiff City | 5-2 |
| 24/01/23 19:45 | Accrington Stanley | Boreham Wood | 1-0a.e.t |