| Date | Home | Away | Result |
|---|---|---|---|
| 02/10/25 17:45 | FC Bologna | SC Freiburg | 1-1 |
| 02/10/25 17:45 | FCSB Bukarest | Young Boys Bern | 0-2 |
| 02/10/25 17:45 | Viktoria Plzen | Malmö FF | 3-0 |
| 02/10/25 17:45 | Celtic Glasgow | Sporting Braga | 0-2 |
| 02/10/25 17:45 | Panathinaikos Athens | Go Ahead Eagles Deventer | 1-2 |
| 02/10/25 17:45 | Fenerbahce Istanbul | OGC Nice | 2-1 |
| 02/10/25 17:45 | AS Roma | OSC Lille | 0-1 |
| 02/10/25 17:45 | Brann Bergen | FC Utrecht | 1-0 |
| 02/10/25 17:45 | PFC Ludogorets Razgrad | Real Betis Sevilla | 0-2 |
| 02/10/25 20:00 | Feyenoord Rotterdam | Aston Villa | 0-2 |
| 02/10/25 20:00 | FC Porto | Red Star Belgrad | 2-1 |
| 02/10/25 20:00 | FC Basel | VfB Stuttgart | 2-0 |
| 02/10/25 20:00 | Olympique Lyon | FC Red Bull Salzburg | 2-0 |
| 02/10/25 20:00 | KRC Genk | Ferencvaros Budapest | 0-1 |
| 02/10/25 20:00 | Maccabi Tel Aviv | Dinamo Zagreb | 1-3 |
| 02/10/25 20:00 | Nottingham Forest | FC Midtjylland | 2-3 |
| 02/10/25 20:00 | SK Sturm Graz | Glasgow Rangers | 2-1 |
| 02/10/25 20:00 | Celta Vigo | PAOK Saloniki | 3-1 |