| Date | Home | Away | Result |
|---|---|---|---|
| 22/10/26 17:45 | Lech Poznan | AFC Sunderland | 1-1 |
| 22/10/26 17:45 | SK Sturm Graz | Olympique Marseille | 1-0 |
| 22/10/26 17:45 | Dinamo Zagreb | NEC Nijmwegen | 2-4 |
| 22/10/26 17:45 | Royale Union Saint-Gilloise | Hapoel Beer Sheva | 4-0 |
| 22/10/26 17:45 | Juventus Turin | Stade Rennes | 2-2 |
| 22/10/26 17:45 | FC Ararat-Armenia | AZ Alkmaar | 0-4 |
| 22/10/26 17:45 | OFI Crete | Bayer 04 Leverkusen | 0-2 |
| 22/10/26 17:45 | Ferencvaros Budapest | SCU Torreense | 4-1 |
| 22/10/26 20:00 | 1899 Hoffenheim | Olympique Lyon | 3-0 |
| 22/10/26 20:00 | Omonia Nicosia | Benfica Lisbon | 1-4 |
| 22/10/26 20:00 | Jagiellonia Bialystok | RSC Anderlecht | 0-3 |
| 22/10/26 20:00 | NK Celje | FC Red Bull Salzburg | 2-2 |
| 22/10/26 20:00 | AFC Bournemouth | AC Milan | 3-0 |
| 22/10/26 20:00 | Besiktas Istanbul | Crystal Palace | 2-2 |
| 22/10/26 20:00 | Olympiakos Piräus | Sparta Prag | 1-0 |
| 22/10/26 20:00 | Celtic Glasgow | Celta Vigo | 1-2 |
| 22/10/26 20:00 | Viktoria Plzen | Levski Sofia | 1-2 |
| 22/10/26 20:00 | Lillestroem SK | Real Sociedad | 0-6 |