| Date | Home | Away | Result |
|---|---|---|---|
| 15/10/26 17:45 | NK Celje | Omonia Nicosia | 0-3 |
| 15/10/26 17:45 | Royale Union Saint-Gilloise | Real Sociedad | 1-1 |
| 15/10/26 17:45 | AZ Alkmaar | Hapoel Beer Sheva | 2-1 |
| 15/10/26 17:45 | Olympique Lyon | Crystal Palace | 3-2 |
| 15/10/26 17:45 | Lech Poznan | Bayer 04 Leverkusen | 0-4 |
| 15/10/26 17:45 | FC Red Bull Salzburg | AC Milan | 0-4 |
| 15/10/26 17:45 | SCU Torreense | AFC Sunderland | 1-2 |
| 15/10/26 17:45 | Sparta Prag | Lillestroem SK | 1-1 |
| 15/10/26 20:00 | Celta Vigo | Juventus Turin | 1-2 |
| 15/10/26 20:00 | AFC Bournemouth | SK Sturm Graz | 3-0 |
| 15/10/26 20:00 | 1899 Hoffenheim | Besiktas Istanbul | 2-3 |
| 15/10/26 20:00 | Ferencvaros Budapest | Viktoria Plzen | 2-1 |
| 15/10/26 20:00 | Olympique Marseille | Olympiakos Piräus | 0-1 |
| 15/10/26 20:00 | Dinamo Zagreb | RSC Anderlecht | 1-0 |
| 15/10/26 20:00 | Benfica Lisbon | Celtic Glasgow | 4-1 |
| 15/10/26 20:00 | Stade Rennes | OFI Crete | 2-1 |
| 15/10/26 20:00 | Jagiellonia Bialystok | FC Ararat-Armenia | 3-1 |
| 15/10/26 20:00 | NEC Nijmwegen | Levski Sofia | 1-1 |