| Date | Home | Away | Result |
|---|---|---|---|
| 11/12/25 17:45 | FC Midtjylland | KRC Genk | 1-0 |
| 11/12/25 17:45 | PFC Ludogorets Razgrad | PAOK Saloniki | 3-3 |
| 11/12/25 17:45 | FC Utrecht | Nottingham Forest | 1-2 |
| 11/12/25 17:45 | Ferencvaros Budapest | Glasgow Rangers | 2-1 |
| 11/12/25 17:45 | Young Boys Bern | OSC Lille | 1-0 |
| 11/12/25 17:45 | VfB Stuttgart | Maccabi Tel Aviv | 4-1 |
| 11/12/25 17:45 | Dinamo Zagreb | Real Betis Sevilla | 1-3 |
| 11/12/25 17:45 | SK Sturm Graz | Red Star Belgrad | 0-1 |
| 11/12/25 17:45 | OGC Nice | Sporting Braga | 0-1 |
| 11/12/25 20:00 | FC Porto | Malmö FF | 2-1 |
| 11/12/25 20:00 | FC Basel | Aston Villa | 1-2 |
| 11/12/25 20:00 | Olympique Lyon | Go Ahead Eagles Deventer | 2-1 |
| 11/12/25 20:00 | Panathinaikos Athens | Viktoria Plzen | 0-0 |
| 11/12/25 20:00 | SC Freiburg | FC Red Bull Salzburg | 1-0 |
| 11/12/25 20:00 | FCSB Bukarest | Feyenoord Rotterdam | 4-3 |
| 11/12/25 20:00 | Celta Vigo | FC Bologna | 1-2 |
| 11/12/25 20:00 | Celtic Glasgow | AS Roma | 0-3 |
| 11/12/25 20:00 | Brann Bergen | Fenerbahce Istanbul | 0-4 |