| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 06/06/23 23:00 | Athletico Paranaense | Club Libertad | Group G | 1-0 |
| 06/06/23 23:00 | Monagas SC | Deportivo Pereira | Group F | 1-0 |
| 07/06/23 01:00 | Boca Juniors | Colo-Colo | Group F | 1-0 |
| 07/06/23 01:00 | Alianza Lima | Club Atletico Mineiro | Group G | 0-1 |
| 07/06/23 01:00 | FBC Melgar | CA Patronato Parana | Group H | 5-0 |
| 07/06/23 03:00 | Club Bolívar | Club Cerro Porteno | Group C | 2-0 |
| 07/06/23 23:00 | Club Nacional de Football | Internacional | Group B | 1-1 |
| 07/06/23 23:00 | Independiente del Valle | Corinthians | Group E | 3-0 |
| 07/06/23 23:00 | Argentinos Juniors | Liverpool F.C. | Group E | 2-1 |
| 08/06/23 01:00 | SD Aucas | Ñublense | Group A | 0-0 |
| 08/06/23 01:30 | River Plate | Fluminense | Group D | 2-0 |
| 08/06/23 01:30 | Palmeiras | Barcelona SC | Group C | 4-2 |
| 08/06/23 03:00 | The Strongest | Sporting Cristal | Group D | 1-2 |
| 08/06/23 23:00 | Metropolitanos FC | Independiente Medellín | Group B | 0-1 |
| 09/06/23 01:00 | Flamengo | Racing Club | Group A | 2-1 |
| 09/06/23 01:00 | Club Olimpia | Atlético Nacional | Group H | 3-0 |