| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 02/05/23 23:00 | Ñublense | SD Aucas | Group A | 2-1 |
| 02/05/23 23:00 | Liverpool F.C. | Argentinos Juniors | Group E | 2-2 |
| 03/05/23 01:00 | Fluminense | River Plate | Group D | 5-1 |
| 03/05/23 01:00 | Corinthians | Independiente del Valle | Group E | 1-2 |
| 03/05/23 01:00 | Atlético Nacional | Club Olimpia | Group H | 2-2 |
| 03/05/23 03:00 | Sporting Cristal | The Strongest | Group D | 1-0 |
| 03/05/23 23:00 | Internacional | Club Nacional de Football | Group B | 2-2 |
| 03/05/23 23:00 | Club Cerro Porteno | Club Bolívar | Group C | 0-4 |
| 04/05/23 01:00 | Colo-Colo | Boca Juniors | Group F | 0-2 |
| 04/05/23 01:30 | Club Atletico Mineiro | Alianza Lima | Group G | 2-0 |
| 04/05/23 01:30 | Barcelona SC | Palmeiras | Group C | 0-2 |
| 04/05/23 03:00 | Independiente Medellín | Metropolitanos FC | Group B | 4-2 |
| 04/05/23 23:00 | Racing Club | Flamengo | Group A | 1-1 |
| 04/05/23 23:00 | CA Patronato Parana | FBC Melgar | Group H | 4-1 |
| 05/05/23 01:00 | Club Libertad | Athletico Paranaense | Group G | 1-2 |
| 05/05/23 03:00 | Deportivo Pereira | Monagas SC | Group F | 2-1 |