| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 04/04/23 23:00 | The Strongest | River Plate | Group D | 3-1 |
| 04/04/23 23:00 | Argentinos Juniors | Independiente del Valle | Group E | 1-0 |
| 04/04/23 23:00 | Alianza Lima | Athletico Paranaense | Group G | 0-0 |
| 05/04/23 01:00 | Independiente Medellín | Internacional | Group B | 1-1 |
| 05/04/23 03:00 | Metropolitanos FC | Club Nacional de Football | Group B | 1-2 |
| 05/04/23 23:00 | SD Aucas | Flamengo | Group A | 2-1 |
| 05/04/23 23:00 | CA Patronato Parana | Atlético Nacional | Group H | 1-2 |
| 06/04/23 01:00 | Ñublense | Racing Club | Group A | 0-2 |
| 06/04/23 01:00 | Club Cerro Porteno | Barcelona SC | Group C | 2-1 |
| 06/04/23 01:30 | Sporting Cristal | Fluminense | Group D | 1-3 |
| 06/04/23 01:30 | Club Bolívar | Palmeiras | Group C | 3-1 |
| 06/04/23 03:00 | Deportivo Pereira | Colo-Colo | Group F | 1-1 |
| 06/04/23 23:00 | Club Atletico Mineiro | Club Libertad | Group G | 0-1 |
| 06/04/23 23:00 | Liverpool F.C. | Corinthians | Group E | 0-3 |
| 07/04/23 01:00 | Monagas SC | Boca Juniors | Group F | 0-0 |
| 07/04/23 01:00 | FBC Melgar | Club Olimpia | Group H | 1-1 |